|Title||Effects of lens care solutions on comfort and tear film stability|
|Author, Co-Author||Tiffany Yuen, Britney Kitamata-Wong, Yixiu Zhou, Wing Li, Meng Lin|
|Abstract|| Purpose: To evaluate comfort and tear film stability after exposure to different lens-care solutions and a saline solution.
Methods: 25 neophytes participated in a prospective, double-masked, randomized, contralateral crossover study. Acuvue 2 lenses (CL) were soaked in control (CC=ClearCare) or test solutions (PM=PureMoist, BT=Biotrue, RL=RevitaLens, SS=0.9% saline) for 7 days to saturate the CL matrix and then used to deliver each solution onto the ocular surface for 2 hrs. The control eye served as control for all visits and was exposed to CC. The test eye was exposed to each test solution at different visits in a randomized order. Visual analog scale questionnaires for comfort (0=poor, 100=excellent) and dryness (0=no dryness, 100=extremely dry) were done at baseline, 10 min and 2 hrs post-insertion. Pre-corneal non-invasive tear break-up time (PC-NITBUT, s) was measured with Medmont Topographer at baseline. Pre-lens NITBUT (PL-NITBUT, s) was measured after 2 hrs and normalized for analysis for each eye and visit (PL-NITBUT/PC-NITBUT).
Results: At 10 min, mean comfort with PM (71±23) was significantly less than CC (84±17; p<0.05), BT (90±10; p<0.05), RL (89±12; p<0.05), and SS (87±16; p<0.05). There was no significant difference in comfort among solutions after 2 hrs. There was no significant difference in dryness among solutions at 10 min or 2 hrs. Normalized PL-NITBUT with RL was significantly greater than CC (p<0.05), while other control-test-paired solutions showed no difference.
Conclusion: There was less comfort with PM at 10 min. Comfort and dryness appeared similar among different solutions at 2 hrs. PL-NITBUT with RL was more stable than CC. Interestingly, SS had similar comfort, dryness, and PL-NITBUT compared to most of the test solutions.
|Affiliation of Co-Authors||University of California Berkeley, School of Optometry, Clinical Research Center, University of California, Berkeley, School of Optometry, Clinical Research Center, Vision Science Graduate Program, University of California, Berkeley, Vision Science Graduate Program, University of California, Berkeley|