|Title||MODIFICATION OF THE NEUROPTICS PUPILLOMETER TO MEASURE NEAR RESPONSE MIOSIS IN CATARACTOUS AND PSEUDOPHAKIC SUBJECTS|
|Author, Co-Author||George Zikos, Rocco Robilotto, Steven Ali, Arkady Selenow, Mike Morris, Amitava Gupta|
|Abstract|| PURPOSE: We have developed a tool to quickly measure the change in pupil diameter to a change in accommodative stimulus for the purpose of testing cataractous and pseudophakic subjects whose near pupillary response has been questioned.
METHODS: This study examined the pupillary near response using an infrared pupillometer (NeurOptics PLR-200) modified with a detachable near target. The right eye of 230 subjects (mean age = 70.9 ± 5.7 years, range 60.0 - 80.8 years) was measured for 5 seconds at 32 fps while the left eye viewed either a distant target at 3 meters or a near target at 30 cm under normal room illumination. Exclusion criteria included medical diagnoses or use of medications known to affect pupil function. Of the 230 subjects, 68 had a diagnosis of cataracts, while 162 had a history of bilateral cataract surgery with monofocal PCIOL at least 3 months prior. 33 of the cataractous subjects had bilateral cataract surgery during the study period and were tested post surgically as well.
RESULTS: Mean distance pupil = 4.33 ± 0.77mm and mean near = 4.10 ± 0.76mm (paired t-test p<0.001). 71% of subjects had measurable near response miosis. A linear regression fit found a weak correlation between near pupil miosis and age (slope = -0.008, R2 of 0.021). Among the cataractous subgroup, mean distance pupil = 4.42 ± 0.70mm and near = 4.12 ± 0.72mm (paired t-test p<0.001). 78% of subjects had measurable near response. Age had a stronger effect on near miosis (slope = -0.018, R2 = 0.125). Among the pseudophakic subgroup, mean distance pupil = 4.25 ± 0.76mm and near = 4.04 ± 0.77mm (paired t-test p<0.001). 70% of subjects had measurable near response. Age had almost no effect on near miosis (slope = -0.002, R2 = 0.001).
CONCLUSIONS: We have demonstrated that with the modification of a simple clinical device, near pupillary response changes can be measured in cataractous and pseudophakic subjects.
|Affiliation of Co-Authors||Institute for Vision Research, MVA, Institute for Vision Research, MVA, Institute for Vision Research, MVA, Elenza, Inc, Elenza, Inc|