Coming in the April 2016 Optometry & Vision Science
Feature Issue: Revolutionary Future Uses of Contact Lenses
Here are brief highlights.
The online copy will be available early-April.
E-Publication Ahead-of-Print now available for all these articles at http://journals.lww.com/optvissci
Anthony J. Adams, OD, PhD, FAAO
Contact Lenses of the Future
For over a decade new materials and technologies have suggested some amazing applications for contact lenses that go well beyond correcting vision. Four experts offer their insights on the possibilities for biosensing, drug delivery and slowing myopia development using contact lenses.
Contact Lenses to Control Myopia
Our authors review how contact lenses are being used to control progression of myopia. By analyzing published patents they see a framework for future development of an ideal myopia controlling contact lens.
Bifocal Contact Lenses Provide Better Myopia Slowing than Spectacles
Our authors research leads them to be quite 'bullish' on the use of soft bifocal contact lenses for slowing the progression of myopia associated with axial elongation of the eye. They feel their study, notably restricting participants to those with eso fixation disparity, provides the best demonstration of myopia control with contact lenses to date.
Novel Soft Contact Lens Shows Potential to Slow Myopia Progression
High myopia, its increasing prevalence, and its consequent relationship to blinding ocular pathologies of the eye concern our authors. Their study, with a newly designed contact lens with positive spherical aberration, showed potential in slowing myopia progression and no sign of a rebound effect.
Delivering Drugs with Contact Lenses
The research and clinical interest have produced considerable advance in materials and measurement, providing exciting progress with contact lenses as a method of drug delivery. Advances in drug retention time, ocular penetration, and disease management outcomes of both human and animal studies are reviewed.
Contact Lenses Used for Multiple Drug Release
Multiple 'comfort' molecules seem needed to address contact lens discomfort. Our authors have engineered silicone hydrogel contact lenses, via molecular imprinting, to control the simultaneous release and rate of a variety of molecules including hydroxypropyl methylcellulose, trehalose, ibuprofen, and prednisolone from a single lens.
Drug Delivery Tested with In Vitro Eye Model
In order to demonstrate prolonged contact lens drug release our authors have developed, and described, an in vitro eye model to simulate tear volume and flow instead of using the traditional vial model. Unlike the vial model, the in vitro eye model demonstrates sustained release of fluconazole (antifungal) from several commercial contact lenses up to 24 hours.
Delivering a Popular Systemic Drug with Contact Lenses
Dexamethasone is a steroid used to treat many inflammatory and autoimmune conditions, such as rheumatoid arthritis and bronchospasm. Our authors offset the anticipated photodegrading properties of dexamethasone in a contact lens delivery mode using UV blocking technologies and incorporation of vitamin E in the contact lens.
Drug Delivery for Children's Eye Problems
Young children with eye diseases such as myopia and retinoblastoma can potentially be treated pharmacologically, but the risk associated with high or poorly controlled drug release, and the need for regular dosing, limits their effectiveness. The authors found the delivery of atropine and roscovitine from model silicone hydrogel materials for these conditions enabled release over two weeks without compromising lens properties.
Contact Lenses as Scaffolds for Stem Cell Treatments
Limbal stem cells continuously replenish the corneal epithelium throughout life, but deficiencies are painful and sight threatening. Our authors review the way advances have enabled contact lenses to be used as a scaffold and carrier for ocular stem cell transplantation.
Detecting Disease with Contact Lenses
The tear film contains biomarkers for various diseases. Tear glucose (for diabetes) and intraocular pressure monitoring -IOP (for glaucoma) are obvious candidates in the authors' review and critical perspective of contact lens use and challenges in monitoring biomarkers for disease.
Glucose Sensing Contact Lenses for Diabetes
Contact lenses with embedded biosensors can signal blood glucose levels to a mobile phone or computer. The authors review these possibilities for diabetes care.
Novel Contact Lens Correction of Presbyopia
The authors introduce a novel contact lens which extends depth of focus, by deliberate manipulation of higher-order spherical aberrations, and compare its visual performance to a commercially-available presbyopic contact lens. They claim to achieve good intermediate and near vision performance in presbyopic participants without compromising distance vision.
Contact Lenses, Photophobia, and Eye Disease
Our authors provide evidence that red, centrally tinted, contact lenses are an effective tool in reducing photophobia in patients suffering from achromatopsia and cone-rod dystrophies.