|Title||Relationship between dry eye disease severity and serology levels in patients diagnosed with rheumatoid arthritis|
|Author, Co-Author||Jasmine Yumori, Dat Trinh, Eric Lee, Tina Escobedo, Gillian Hollands, Robert Gordon, Cheng-Tong Wang, Thang Le, Anthony Hou, Michael Finley|
|Abstract|| Purpose: The purpose of this study was to examine the relationship between dry eye disease (DED) severity and serology levels in patients diagnosed with rheumatoid arthritis (RA).
Method: This prospective, observational multi-center clinical study involved 286 adult patients diagnosed with RA. Patients were recruited from non-eye care settings. The following serological lab tests were performed: Cyclic Citruillinated Peptide IgG antibody (CCP), Rheumatoid Factor (RF), and C-Reactive Protein (CRP). The following dry eye tests were performed: Ocular Surface Disease Index® (OSDI), tear osmolarity (TO), tear break-up time (TBUT), corneal/conjunctival staining, and Schirmer test (ST) without anesthetic. A Modified Dry Eye WorkShop (DEWS) Severity Scale was created to quantify DED severity level. A DED severity level was determined for each eye by averaging the severity level for each test. The eye with the higher DED severity level was used to identify each patient’s overall DED severity level. For statistical analysis, the Spearman correlation test was used.
Results: Data from the 286 RA patients was analyzed. Mean serological lab test results are: CCP 91.77+/-105.80, RF 77.44+/-109.73, and CRP 0.58+/-1.58. Mean dry eye test results are: OSDI 37.21+/-25.54, TO 316.26+/-16.32, TBUT 4.20+/-2.05, staining 4.45+/-4.52, and ST 11.15+/-8.99. The prevalence of DED in RA patients recruited from non-eye care settings is 96.15%.
There was a significant correlation between higher DED severity levels and elevated CCP and RF levels (Spearman’s rho = 0.16 [p=0.01] and = 0.23 [p=0.0005], respectively). There was not a statistically significant correlation between DED severity and CRP levels.
Conclusion: In this population of adult RA patients recruited from non-eye care settings there is a statistically significant correlation between DED severity and both CCP and RF levels. Serological lab test results may allow eye care practitioners to better care for DED in patients with RA.
|Affiliation of Co-Authors||Western University of Health Sciences, Inland Rheumatology and Osteoporosis Medical Group, Western University of Health Sciences, Western University of Health Sciences, Western University of Health Sciences, University of California, Irvine, Inland Rheumatology and Osteoporosis Medical Group, Inland Rheumatology and Osteoporosis Medical Group, Western University of Health Sciences|