The role of OCT angiography in detection of microaneurysms in patients with diabetes mellitus

Title The role of OCT angiography in detection of microaneurysms in patients with diabetes mellitus
Author, Co-Author Jessica Steen
Topic Treatment and Management of Posterior Sgmt Disease
Program Number
Ballroom A-B
Nova Southeastern University, College of Optometry

Background: Microaneurysms are the earliest markers of diabetic retinopathy, which are often not apparent on clinical examination alone. Their presence is an indication of progression of diabetic retinopathy which makes them important to recognize for the prevention of progression to vision threatening diabetic retinopathy. Optical coherence tomography angiography (OCTA) is a non-invasive imaging technique used to visualize retinal and choroidal vasculature including retinal capillary detail with high-resolution.

Case series: Three female patients aged 62-68 with diabetes mellitus type II duration 16-32 years with clinical level of diabetic retinopathy (DR) ranging from no diabetic retinopathy to proliferative diabetic retinopathy (International Clinical Disease Severity Scale for DR) underwent 3x3 OCT angiography centered at the fovea (Zeiss Angioplex) following clinical examination. Superficial OCTA images were overlaid on fundus photographs. Microaneurysms were qualitatively identified as round, hyperreflective, focal outpouching of retinal capillaries on OCTA which were not visible on fundus photography.

Conclusion: OCT angiography is useful in identifying microaneurysms which are not apparent on clinical examination. A practical method for the detection and evaluation of microaneurysms on OCTA is needed to improve the management of patients with diabetes mellitus. Early detection of diabetic retinopathy is essential to prevent progression to later stages of diabetic retinopathy and associated vision loss.

Affiliation of Co-Authors