Study on pathological changes and the expression of hepatocyte growth factor of extraocular muscle in concomitant strabismus

Title Study on pathological changes and the expression of hepatocyte growth factor of extraocular muscle in concomitant strabismus
Author, Co-Author Lianhong Zhou
Topic
Year
2015
Day
Thursday
Program Number
155017
Room
Great Hall Foyer
Affiliation
Abstract Purpose: To study on pathomorphological changes and the expression of hepatocyte growth factor of extraocular muscle in concomitant strabismus.
Methods: Fifty-eight concomitant strabismus patients were collected as strabismus group and 10 normals were selected as control group. Strabismus patients were divided into concomitant exotropia group 32 cases and concomitant esotropia group 26 cases. All the resected tissues of the rectus muscles were obtained from patients with concomitant strabismus during resection surgery and cornea donators. HGF was measured its mean average optical by SABC method of immunohistochemistry using image analyzer. The amounts of HGF in the resected muscle of patients were compared with normals, as well as correlated clinical data of patients such as age, degree of deviation.
Results: The amounts of cross-sectional area of muscle fiber in the resected rectus muscle of patients with constant exotropia(308.89±68.39) μm2 and constant esotropia(217.91±34.73)μm2 were significantly lower than those of normal respectively ( P < 0.05). Masson staining observation, the weak side of extraocular muscle in patients with concomitant strabismus were showed the decreased in the number of muscle fibers, the increased in the collagen fiber content, disordered arrangement, than normal control group. The amounts of HGF in the resected rectus muscle of patients with constant exotropia and constant esotropia were significantly lower than those of normal respectively ( t=6.3270, 4.7524,P < 0.05). żThe amounts of HGF had negative relationship with age and degree of deviation.
Conclusion: The decreased level of HGF expression may participate in the incidence of concomitant strabismus. The changement of the expression of HGF in extraocular muscles may result in deteriorating of concomitant strabismus.
Affiliation of Co-Authors
Outline