WHICH ARTIFICIAL TEAR DO PATIENTS PREFER FOR EVAPORATIVE DRY EYE?

Title WHICH ARTIFICIAL TEAR DO PATIENTS PREFER FOR EVAPORATIVE DRY EYE?
Author, Co-Author Srihari Narayanan, Charles Connor, Laura Schroeder, Raelyn Ottenbreit, Jeff Rabin
Topic
Year
2013
Day
Program Number
135774
Room
Room 6C
Affiliation
University of the Incarnate Word, Rosenberg School of Optometry
Abstract PURPOSE:
Artifical Tears (AT) with an added lipid component are available for evaporative dry eyes – a common mechanism for dry eye disease. This study compares patient preference for 3 AT’s designed for evaporative dry eye: Allergan Refresh Optive Advanced (Optive), Alcon Systane Balance (Balance) and Ocusoft Retaine (Retaine).

METHODS:
Twenty five subjects (15F, 10M; mean age 25.4+/-2.9 yrs) were included based on short (<10 secs) non-invasive tear breakup time (NITBUT). Subjects compared the 3 products for 2 weeks. NITBUT was measured at baseline and after 2 weeks of use.  At the end of each 2-week period, subjects were asked if the drop was comfortable and if they would buy it. We compared the subjects’ responses to two other indicators: 1. OSDI score (a score <20 for mild dry eye and >20 for a severe condition); 2. Level of Meibomian gland dysfunction (MGD) (score of 1 or more on the Efron scale considered MGD). ANOVA with a post-hoc test was done to test significance at the p=0.05 level.

RESULTS:
NITBUT improved following use of Optive (6.2 to 9 seconds; p< 0.05) and Balance (7.5 to 8.3 seconds; p<0.05) but not with Retaine (7 to 6.3 seconds). Comfort was best for Optive (84% subjects) followed by Balance (68%) and Retaine (56%; p<0.05 compared to Optive). No difference noted for which product subjects would buy. The trend was Optive (60%), followed by Balance (48%) and Retaine (32%). No preference noted for subjects with higher OSDI score, though the trend was Optive, followed by Balance and Retaine. Equal preference was noted for Optive and Balance based on MGD severity.

CONCLUSIONS:
The results of our study show a general trend of Optive being preferred by our subjects, followed closely by Balance and Retaine. The data suggests that it is appropriate to target the use of these particular AT’s to patients with evaporative dry eye.

Affiliation of Co-Authors University of the Incarnate Word, Rosenberg School of Optometry, University of the Incarnate Word, Rosenberg School of Optometry, University of the Incarnate Word, Rosenberg School of Optometry, University of the Incarnate Word, Rosenberg School of Optometry
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