Leber's idiopathic stellate neuroretinitis (LISN) is an uncommon, self-limiting condition which presents with unilateral optic disc swelling followed by a macular star. Patients are usually younger than 50 and have had recent symptoms of viral illness or prodrome. Prognosis is excellent for visual recovery and ultimate resolution of macular star. Presented here is the work-up and differential diagnosis of two young women who presented with atyptical courses in relation to LISN. In case 1 macular depostion was not initially stellate in appearance suggesting a preliminary diagnosis of toxocara or toxoplasmosis. Case 2 presented with neuroretinitis in the first eye, a cotton wool spot and an elevated sedementation rate with mild involvement of the fellow eye. Because LISN is a diagnosis of exclusion, clinicians must be able to differentially diagnose the infectious agents which may be directly responsible in producing neuroretinitis.