CLINICAL PERFORMANCE OF A MULTI-PURPOSE CARE SOLUTION FOR HYDROGEL CONTACT LENSES IN A MODIFIED "NO-RUB" REGIMEN

Jack Stoecker

Abstract

PURPOSE. Many contact lens wearers do not fully comply with rubbing of lenses on a daily basis. To provide a potential option for these patients, clinical performance of a multipurpose contact lens solution (MPS-1, Allergan, Inc.) used in a modified "no-rub" regimen was tested in a crossover design versus a marketed "rub and rinse" product (MPS-2, Bausch & Lomb, Inc). METHOD. One hundred twenty subjects, wearing hydrogel lenses to be replaced every 30 days, were enrolled in an investigator-masked two-period crossover study of two months duration. Lens wearing comfort (scored on a scale of 0-10), visual acuity, and slit lamp examination findings were evaluated at Day 0 (baseline), and at 7 and 30 days of each treatment period. Acceptability questionnaires were completed at the end of each treatment period and a preference questionnaire was completed at the end of the study. Lenses were collected at the end of each period and analyzed for visible deposits by dark-field microscopy and computer image analysis, and for total protein content by a modified Lowry method.

RESULTS. One hundred fourteen subjects (95.0%) completed the study. There was no statistically significant difference between regimens in mean change from baseline in lens comfort score, symptoms of discomfort, visual acuity, or slit lamp examination findings. Statistically significant differences between treatment regimens were observed in end-of-treatment acceptability and preference, with the majority of responses favoring MPS-1 over MPS-2. Laboratory analysis of lens deposits and total lens protein did not demonstrate any statistically significant differences between regimens.

CONCLUSIONS. Use of a multipurpose solution in a modified, "no-rub" regimen for cleaning and disinfection of hydrogel lenses replaced at 30 days is a safe and acceptable alternative to a standard "rub and rinse" regimen. The "no-rub" regimen was preferred overall and may be indicated for patients who have difficulty complying with mechanical cleaning of hydrogel lenses.

Details

Year: 2001

Program Number: Poster 145

Author Affiliation: Allergan, Inc

Co-Authors: Judy Donnelly, Peter Simmons, Marcel VanLeuven, Richard Kalman

Co-Author Affiliation: n/a

Room: Exhibit Hall C