THE CLINICAL PERFORMANCE OF A POLYQUAD-BASED CARE REGIMEN WITH A SILICONE-HYDROGEL MATERIAL USED ON A DAILY-WEAR BASIS

Nancy MacDougall

Abstract

PURPOSE. The recent release of novel silicone-hydrogel (SH) lenses has proven valuable in the management of patients who wish to wear lenses on an overnight basis. However, many subjects choose to use such lenses on a daily-wear modality, necessitating the use of a daily cleaning and disinfection regime. To-date there has been little published information concerning the safety of using multipurpose care regimes with SH materials. The purpose of this study was to determine the clinical performance and safety of a polyquad-based care regimen (OPTI-FREE Express, Alcon) when used to disinfect a silicone-hydrogel (SH) lens material (Balafilcon; PureVision, B&L). METHOD. A one-month prospective clinical trial was conducted in which 50 myopic subjects (mean age 28 ± 8.4 years, mean sphere-3.25 ± 1.5D) who were successful wearers of hydrogel contact lenses were refitted with PureVision SH lenses on a daily-wear basis. Subjects were assigned OPTI-FREE Express (using a pre- and post-wear rinsing procedure) as the care regimen and clinically reviewed at dispensing and after 14 and 28 days.

RESULTS. Two subjects were unable to complete the study, due to lens-related issues (one due to discomfort and the other due to a SEAL). Subjects wore their lenses for an average of 11.1 ± 2.6 hours per day. There were no reports of excessive stinging or burning following lens insertion. Subjective ratings of lens comfort reduced (p<0.001) and dryness increased (p<0.001) over the day of wear, in parallel to that experienced with other combinations of lenses and care regimes. Minimal amounts of corneal and conjunctival staining were observed and there were no significant changes in palpebral lid appearance or limbal hyperemia over the time-course of the study (p=NS).

CONCLUSIONS. These results support the safety and viability of using a polyquad-based care regimen for the daily disinfection of Balafilcon-based lenses.

Details

Year: 2001

Program Number: Poster 140

Author Affiliation: Centre for Contact Lens Research

Co-Authors: Luigina Sorbara, Lyndon Jones, Desmond Fonn

Co-Author Affiliation: University of Waterloo, University of Waterloo

Room: Exhibit Hall C