The efficacies of six F.D.A. approved soft contact lens disinfecting solutions were evaluated against the fungal contaminant, *Beauveria bassiana.. *Beauveria bassiana is a ubiquitous soil fungus with a demonstrated ability to grow into a soft contact lens matrix. A stock solution of the fungus was prepared and aliquots were added to each of the following disinfection systems: ReNu, Opti-Free, AOSEPT, OxyTab, UltraCare, and a Softmate Thermal Disinfecting Unit. Hydrogen peroxide systems were neutralized immediately using the manufacturer's recommended method. After 1 minute, 5 minutes, 15 minutes, 30 minutes, 1 hour, 4 hours, and 8 hours, aliquots were removed, added to neutralizing broth, and streaked onto Sabouraud's Dextrose Agar plates. AOSEPT, OxyTab, UltraCare and heat disinfection were effective in destroying 100% of the viable spores within 5 minutes. ReNu showed a D-value of 1 to 4 hours, but then exhibited a statistically significant rebound in the number of colony forming units at 8 hours. Opti-Free was the least effective with typically only 15-25% of the viable spores being destroyed even after 8 hours. Study funded by Allergan, Inc.