Sixty contact lens patients, diagnosed as having advanced contact lens related giant papillary conjunctivitis (GPC), were studied to compare the efficacy of three different contact lens designs in the management of the condition. After cessation of previous lens wear, and stabilization of the condition to Grade III GPC or less, each subject was assigned, randomly, to one of three experimental groups. Group I subjects were fitted with 13.8 diameter CSI (CSI) daily wear lenses, group II subjects were fitted with SeeQuence (SE) lenses, and group III subjects were fitted with Acuvue (AV) lenses. All subjects were instructed in the prescribed care and handling of the lenses and were instructed to wear their lenses on a daily wearing schedule not to exceed 14 hours per day. Group I wore the same pair of lenses throughout the study, except for replacement of lost or damaged lenses. Groups II and III were instructed to replace thier lenses every two weeks during the study. Lens tolerance, symptomology and objective signs of GPC were monitored periodically throughout the 60 week study. The results showed that signs and symptoms of GPC improved for all groups during the course of the study. No difference in improvement, between groups, was noted during the first 24 weeks of study. Beginning on the 36th week of the study, however, groups II (SE) and III (AV) showed significantly more improvement, both subjectively and objectively than did Group I (CSI). From these results we conclude that SeeQuence or Acuvue lenses, used on a dialy wear basis, are a preferable modality for the long term management of GPC.