Evaporative dry eye treatment with Retaine MGD artificial tears OR intraductal Meibomian gland probing... a comparison

Srihari Narayanan

Abstract

Purpose: Dry eye, a common clinical problem, is most frequently caused by rapid tear evaporation. Blockage of the Meibomian glands (MG) is a major cause of the increased tear evaporation. Intraductal meibomian gland probing (IMGP) is an innovative treatment for Meibomian gland dysfunction (MGD). This study compares an artificial tear (Ocusoft Retaine MGD) designed to treat evaporative dry eye with IMGP in patients who have MGD.

Methods: Twenty subjects with obstructive MGD based on signs and symptoms participated in this study. Subjects were assigned into two groups of 10, where they received either IMGP or Retaine MGD artificial tears. The IMGP group had a mean age of 44.5 years with 6 females. The Retaine group had a mean age of 26.6 years with 6 females. The artificial tear group used the drop four times a day for four weeks. The IMGP group received a single treatment of probing. All subjects were given the Ocular Surface Disease Index (OSDI) questionnaire and Tear Breakup Time (TBUT) at baseline and at 4 weeks post treatment. The data was analyzed by ANOVA with post hoc test for significance.

Results: Baseline OSDI score for the IMGP group was 31.9+/-16.7 which decreased to 16.2 +/- 14.6 at 4 weeks post treatment. This 52% decrease in symptoms was significant (p<0.01). Baseline OSDI for the Retaine group was 38.4+/-16.1 which decreased to 33.5+/-13.2 after 4 weeks. Baseline TBUT for the IMGP group was 3.45+/-2 seconds, which improved to 7.85+/- 6.9 seconds (p<0.05) at the 4 week visit. The Retaine group had a baseline TBUT of 3.3+/- 2.1 which was not statistically different from the 4 week visit at 3.25 +/- 2.2 seconds.

Conclusions: Subjects in the IMGP group showed over 50% improvement in symptoms as well as a doubling of TBUT. These results suggest that intraductal Meibomian gland probing is more efficacious than artificial tears alone to treat MGD.

Details

Year: 2014

Program Number: 145023

Resource Type: Scientific Program

Author Affiliation: Univ. of the Incarnate Word Rosenberg School of Optometry

Co-Authors: Chandra Mickles, Charles Connor, Desirae Brinkley, Samantha Bohl

Co-Author Affiliation: University of the Incarnate Word Rosenberg School of Optomet, University of the Incarnate Word Rosenberg School of Optomet, University of the Incarnate Word Rosenberg School of Optometry, University of the Incarnate Word Rosenberg School of Optometry

Room: Four Seasons Ballroom