Influence of Age and Race on Axial Elongation in Myopic Children

Noel Brennan

Abstract

Purpose: In evidence-based medicine, well-conducted meta-analyses provide the highest quality of scientific evidence. Donovan et al published a meta-analysis of refractive progression among myopes; 1 however, axial length may be a preferred metric to refractive error for assessing myopia as
(i) it is significantly associated with retinal disease,
(ii) its measurement is more repeatable (in relative terms) and
(iii) it can be obtained without cycloplegia.
We conducted a meta-analysis to model axial elongation in myopic children.

Methods: A search using PubMed and Embase, based on the following search terms ["myopi* AND ((axial AND (length OR elongation)) OR biometr*) AND (progression OR shift OR longitudinal) NOT (animal OR surgery OR surgical OR adult)], yielded 269 results. Data from 63 eligible studies was available after eliminating reviews, studies without progression data specifically for myopes in the age range of 7 to 18 years and papers with redundant information or other sundry issues, and adding studies cross-referenced in the papers surveyed. To account for varying ages of sample populations and different periods of follow-up, instantaneous axial elongation rate was modeled using the integral of the exponential decay function based on the following equation:
AEt,t' = (eλt' - eλt) * α/λ, where AEt,t' is measured axial elongation between ages t and t' and α and λ are fitted constants. A procedure was developed to score race in different studies with ethnicity, country of residence and proportional representation in studies taken into account.

Results: Graph A of the figure plots adjusted residuals after modeling instantaneous rate of axial elongation (mm/yr) by age and race (see caption for details). 79% of measured values fall within ± 0.10 mm of fitted values. Graph B plots the model (R 2 = 0.82). Asian children show about 44% greater rate of elongation than non-Asians across age despite independence of fit of the decay functions. A 9yo Asian child is predicted to have instantaneous progression of 0.41 mm/yr compared with 0.28 mm/yr for a 9yo white child. These rates of axial elongation are generally compatible with refractive progression curves of Donovan et al 1, although differences between Asian and non-Asian children are greater than expected.

Conclusion: To our knowledge, this is the first meta-analysis of axial elongation in myopic children. Axial length measurement is expected to become an increasing part of clinical practice as myopia control becomes more widely accepted. Our model provides a useful referent for practitioners when assessing myopic progression in children and may assist in setting efficacy criteria for myopia control products. Future work will identify important covariates beyond race and age, the change in the axial length/refractive error ratio and progression rates during various forms of myopia control treatment.
1. Donovan et al, Optom Vis Sci 2012; 89: 27.

Details

Year: 2018

Program Number: 180072

Resource Type: Scientific Program

Author Affiliation: Johnson & Johnson Vision

Co-Authors: Xu Cheng, Youssef Toubouti, Mark Bullimore

Co-Author Affiliation: Johnson & Johnson Vision, Johnson & Johnson Vision, Marshall B. Ketchum University

Room: Room 304